Androgen signaling is critical to the development and maintenance of male sexual characteristics. It also plays a pivotal role in female physiology and reproduction. Androgen has been linked with many diseases, including prostate cancer, breast cancer, diabetes, metabolic syndrome and Alzheimer's disease. Thus, fully understanding the androgen action is of fundamental significance.
Androgen Responsive Gene Database (ARGDB) aims to provide integrated knowledge on androgen controlled genes. Records were collected on the basis of online literature collections of PubMed. More than 6000 abstracts together with 950 original publications were manually screened, which makes ARGDB different from databases built in an automatic way. 1785 human genes, 993 mouse genes and 583 rat genes were included in the database. They were all experimentally proved to be regulated by androgen. ARGDB was integrated with multiple resources including NCBI, GO and KEGG pathway. It is mainly composed of 4 modules including Browse, Search, Element Scan and Submission, aiming to be a unified gateway to storage, retrieval and update of information on androgen-regulation genes.
Please acknowledge ARGDB in your publications by citing the following reference: Jiang M, Ma Y, Chen C, Fu X, Yang S, Li X, Yu G, Mao Y, Xie Y, Li Y. Androgen-responsive gene database: integrated knowledge on androgen-responsive genes. Mol Endocrinol. 2009 Nov;23(11):1927-33. [PUBMED]